| Sep. 5 Monday | at Georgia Tech Yellow JacketsMercedes-Benz Stadium, Atlanta, GA | Time TBA ETTV TBA | Buy Tickets |
| Sep. 10 Saturday | Furman PaladinsMemorial Stadium, Clemson, SC | Time TBA ETTV TBA | Buy Tickets |
| Sep. 17 Saturday | Louisiana Tech BulldogsMemorial Stadium, Clemson, SC | Time TBA ETTV TBA | Buy Tickets |
| Sep. 24 Saturday | at Wake Forest Demon DeaconsTruist Field, Winston-Salem, NC | Time TBA ETTV TBA | Buy Tickets |
| Oct. 1 Saturday | NC State WolfpackMemorial Stadium, Clemson, SC | Time TBA ETTV TBA | Buy Tickets |
| Oct. 8 Saturday | at Boston College EaglesAlumni Stadium, Chestnut Hill, MA | Time TBA ETTV TBA | Buy Tickets |
| Oct. 15 Saturday | at Florida State SeminolesDoak Campbell Stadium, Tallahassee, FL | Time TBA ETTV TBA | Buy Tickets |
| Oct. 22 Saturday | Syracuse OrangeMemorial Stadium, Clemson, SC | Time TBA ETTV TBA | Buy Tickets |
| Oct. 29 Saturday | OFF | | |
| Nov. 5 Saturday | at Notre Dame Fighting IrishNotre Dame Stadium, Notre Dame, IN | Time TBA ETTV TBA | Buy Tickets |
| Nov. 12 Saturday | Louisville CardinalsMemorial Stadium, Clemson, SC | Time TBA ETTV TBA | Buy Tickets |
| Nov. 19 Saturday | Miami (FL) HurricanesMemorial Stadium, Clemson, SC | Time TBA ETTV TBA | Buy Tickets |
| Nov. 26 Saturday | South Carolina GamecocksMemorial Stadium, Clemson, SC | Time TBA ETTV TBA | Buy Tickets |
| Dec. 3 Saturday | ACC ChampionshipBank of America Stadium, Charlotte, NC | Time TBA ETTV TBA | Buy Tickets |